Melanotan 1 Peptide 10mg – Protide Health USA

Melanotan 1 Overview & Technical Specifications

Melanotan 1 is a synthetic 13-amino-acid analogue of alpha-melanocyte-stimulating hormone, commonly abbreviated α-MSH.

The molecule is also known scientifically as afamelanotide and NDP-MSH.

Its sequence is:

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

Compared with endogenous α-MSH, Melanotan 1 contains two important amino-acid modifications:

• Methionine at position 4 is replaced by norleucine
• L-phenylalanine at position 7 is replaced by D-phenylalanine

These substitutions increase resistance to enzymatic degradation and alter melanocortin-receptor pharmacology relative to native α-MSH.

Protide Health supplies Melanotan 1 as 10mg of 99% purity, HPLC-MS verified, third-party tested lyophilized research material in a 3mL vial.

Technical Specifications

• Product Name: Melanotan-1
• Scientific Name: Afamelanotide
• Alternative Names: Melanotan I, MT-1, MT-I, NDP-MSH, [Nle4,D-Phe7]-α-MSH
• Quantity: 10mg
• Form: Lyophilized powder
• Vial Size: 3mL
• Purity: 99%
• Testing: HPLC-MS verified; third-party tested
• Peptide Type: Synthetic tridecapeptide α-MSH analogue
• Peptide Length: 13 amino acids
• Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂
• CAS Number: 75921-69-6
• PubChem CID: 16197727
• Molecular Formula: C78H111N21O19
• Molecular Weight: approximately 1646.87 g/mol
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in water
• Storage: Store sealed at ≤6°C and protected from heat, light, and moisture
• Research Use: Melanocortin-receptor, pigmentation-pathway, biochemical, cellular, analytical, and qualified preclinical research only

Melanotan 1 Peptide Structure & α-MSH Analogue Research

The Melanotan 1 peptide retains the 13-residue framework of endogenous α-MSH while incorporating the Nle4 and D-Phe7 substitutions.

These modifications are represented by the historical research name:

[Nle4,D-Phe7]-α-MSH

or:

NDP-MSH

The resulting molecule has been studied extensively in melanocortin receptor and melanogenesis research.

Areas of investigation include:

• MC1R activation
• Melanocyte signaling
• Adenylate cyclase
• Cyclic AMP
• Melanin synthesis
• Eumelanin production
• Pigmentation biology
• α-MSH structure-activity relationships

Melanotan 1 & MC1R Research

A principal molecular target associated with Melanotan 1 is the melanocortin-1 receptor, or MC1R.

MC1R is a G protein-coupled receptor expressed prominently in melanocytes.

Activation can influence signaling involving:

• Gs proteins
• Adenylate cyclase
• Cyclic AMP
• Protein kinase A
• MITF-associated transcription
• Melanogenic enzymes
• Eumelanin synthesis

Afamelanotide research has demonstrated strong MC1R-associated melanogenic activity.

These mechanistic findings do not make the Protide Health vial a tanning product or approved medical formulation.

What Makes Melanotan 1 Different From α-MSH?

Natural α-MSH has the sequence:

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

Melanotan 1 modifies two positions:

Position 4

Natural α-MSH:

Met

Melanotan 1:

Nle

Position 7

Natural α-MSH:

L-Phe

Melanotan 1:

D-Phe

These structural substitutions contribute to increased stability and altered receptor pharmacology compared with the endogenous hormone.

Melanotan 1 vs 2

The keyword melanotan 1 vs 2 compares two related but structurally distinct α-MSH analogues.

Researchers may review Melanotan 2 10mg as a separate Protide Health research compound.

Melanotan 1

Melanotan 1:

• Contains 13 amino acids
• Is a linear α-MSH analogue
• Is also known as afamelanotide
• Closely preserves the α-MSH peptide framework
• Is strongly associated with MC1R/melanogenesis research

Melanotan 2

Melanotan II:

• Is a cyclic seven-amino-acid analogue
• Is considerably shorter
• Has broader melanocortin-receptor pharmacology
• Is studied in MC1R, MC3R, MC4R, and related melanocortin systems

The melanotan 1 vs 2 comparison should therefore focus on molecular structure, receptor pharmacology, and research application rather than declaring one compound universally superior.

Melanotan 2 vs 1

The reversed search phrase melanotan 2 vs 1 involves the same structural distinction.

Melanotan I is a linear tridecapeptide, while Melanotan II is a cyclic heptapeptide.

Researchers should not transfer:

• Receptor-selectivity data
• Safety observations
• Experimental outcomes
• Pharmacokinetic findings

from one analogue automatically to the other.

The two compounds are related through α-MSH research but are not interchangeable.

Melanotan 1 vs PT-141

PT-141, also called bremelanotide, developed from the broader melanocortin analogue research field.

Researchers can review PT-141 10mg for a separate cyclic melanocortin research peptide.

Melanotan 1 and PT-141 differ in:

• Sequence
• Peptide length
• Cyclization
• Molecular formula
• Receptor profile
• Development history
• Regulatory context

They should therefore be treated as separate research materials.

Melanotan 1 Before and After Search Intent

The phrase melanotan 1 before and after generally refers to consumer pigmentation photographs.

Such images are not strong scientific evidence because they commonly lack:

• Standardized lighting
• Objective pigment measurements
• Matched ultraviolet exposure
• Verified compound identity
• Product purity data
• Control groups
• Consistent camera settings
• Baseline melanocortin-receptor characterization

Controlled studies instead use defined measurements of pigmentation, melanin density, photobiological response, or related endpoints.

Protide Health therefore does not use melanotan 1 before and after imagery as proof of product efficacy.

Melanotan 1 & Pigmentation Research

Human experimental research with NDP-MSH / afamelanotide has demonstrated increased melanin pigmentation under controlled study conditions.

Studies have investigated:

• Melanin synthesis
• Skin pigmentation
• MC1R genetic variants
• UV-associated responses
• Eumelanin production
• Photobiology

One controlled study involving individuals with different MC1R genotypes found that Melanotan/NDP-MSH increased eumelanin-related pigmentation even among participants carrying certain MC1R variants.

These findings apply to defined clinical research formulations and protocols.

They do not establish human suitability of the Protide Health research material.

Melanotan 1 Dosage Search Context

The phrase melanotan 1 dosage generally concerns human administration.

Protide Health does not provide human dosing guidance.

The 10mg quantity on this page describes the total amount of research material supplied in the vial.

It is not a recommended dose.

No instructions are provided for:

• Human injection
• Daily administration
• Weekly administration
• Titration
• Body-weight calculation
• Tanning protocols
• Reconstitution for administration
• Treatment cycles

Published afamelanotide or historical Melanotan I research protocols should not be converted into instructions for independently supplied research material.

Melanotan 1 Dosage Chart PDF Searches

The phrase melanotan 1 dosage chart pdf specifically reflects interest in a human-use dosing chart.

Protide Health does not provide a dosage chart or administration schedule.

This product page therefore does not include:

• Dose-by-body-weight charts
• Injection schedules
• Loading protocols
• Maintenance schedules
• UV exposure schedules
• Reconstitution charts

The 10mg specification describes vial contents only.

Melanotan 1 for Sale: Research Sourcing Context

The phrase melanotan 1 for sale has transactional search intent.

For laboratory sourcing, researchers should evaluate factors such as:

• Correct molecular identity
• Verified sequence
• Defined purity
• HPLC-MS testing
• Appropriate storage
• Analytical documentation
• Research-only labeling

Protide Health specifies Melanotan 1 as 99% purity, HPLC-MS verified, and third-party tested.

Researchers comparing the broader research-peptide marketplace may also review this peptide science alternativeresource.

This product is not sold by Protide Health for tanning, personal use, self-administration, or clinical treatment.

Afamelanotide & Melanotan 1 Terminology

The molecular identity commonly called Melanotan 1 is also known as afamelanotide.

Afamelanotide has been developed pharmaceutically in a regulated sustained-release implant formulation.

This creates an important distinction:

Molecular Identity

Melanotan 1 / afamelanotide refers to:

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

Approved Pharmaceutical Product

A regulated afamelanotide implant exists under the trade name SCENESSE.

Protide Health Product

The Protide Health material is a 10mg lyophilized research vial.

It is not SCENESSE, is not an approved implant, and should not be represented as equivalent to the pharmaceutical product.

Regulatory Context of Afamelanotide

Afamelanotide received FDA approval in 2019 in the form of a controlled-release implant for a specific indication involving erythropoietic protoporphyria.

That approval applies to the regulated pharmaceutical product, its formulation, manufacturing controls, labeled indication, and administration system.

It does not mean that independent Melanotan-1 research material is FDA approved.

The Protide Health product remains strictly a laboratory research material.

Melanotan 1 Peptide & Melanogenesis

Melanogenesis describes the biological production of melanin.

MC1R activation in melanocytes can increase cAMP-associated signaling and influence production of eumelanin.

Research involving Melanotan 1 peptide has therefore investigated:

• MC1R pharmacology
• Tyrosinase-associated pathways
• Eumelanin
• Melanocyte signaling
• UV-response biology
• Pigmentation measurements

These are scientifically established areas of study but do not justify marketing a research vial as a cosmetic tanning product.

MC1R Genetic Variation Research

MC1R exhibits substantial human genetic variation.

Some MC1R variants are associated with differences in:

• Pigmentation phenotype
• Red-hair phenotype
• Skin phototype
• Melanogenic signaling
• Response to endogenous α-MSH

Clinical research involving afamelanotide has examined whether MC1R variants influence pigmentation response.

This makes Melanotan 1 useful as a research ligand for studying receptor genotype and melanocyte-response relationships.

Melanotan 1 Safety & Evidence Context

Human studies exist for regulated afamelanotide formulations, while unregulated α-MSH analogue use has also been discussed in clinical literature.

These categories should not be combined.

Safety findings from an approved implant cannot establish safety for:

• Independently produced research vials
• Unknown formulations
• Different manufacturing conditions
• Different administration routes
• Unmonitored use

Published reviews have specifically raised concerns regarding unregulated human use of Melanotan I and Melanotan II.

Protide Health therefore makes no human safety claim for this product.

Research Applications

Qualified laboratories may investigate Melanotan 1 in models involving:

• MC1R signaling
• Melanogenesis
• α-MSH structure-activity relationships
• cAMP signaling
• Melanocyte biology
• Pigmentation pathways
• Melanocortin receptor binding
• Peptide stability
• Receptor genotype-response relationships
• Analytical peptide characterization

Experimental conditions should be selected according to validated methodology.

Research Format & Storage

Protide Health supplies Melanotan 1 as:

• Quantity: 10mg
• Form: Lyophilized powder
• Vial Size: 3mL
• Purity: 99%
• Testing: HPLC-MS verified; third-party tested
• Appearance: White to off-white
• Solubility: Soluble in water

Storage specifications:

• Store at ≤6°C
• Keep sealed
• Protect from heat
• Protect from direct light
• Protect from moisture

These specifications describe laboratory storage conditions only.

Research Limitations

Several limitations are important when interpreting Melanotan 1 research:

• Melanotan 1 is a synthetic α-MSH analogue rather than endogenous α-MSH.
• Melanotan 1 and Melanotan 2 are chemically different.
• Findings from Melanotan 2 should not automatically be assigned to Melanotan 1.
• Approved afamelanotide implant research does not establish suitability of an independent lyophilized research vial.
• Pigmentation findings do not establish cosmetic-use approval.
• Before-and-after photographs are not controlled scientific evidence.
• MC1R responses can vary with genotype and experimental context.
• Unregulated α-MSH analogue use has raised safety concerns.
• The 10mg vial quantity is not a human dosage.
• The Protide Health product is not the FDA-approved SCENESSE implant.

For these reasons, Melanotan 1 peptide is supplied strictly for qualified laboratory research.

Literature & Citation Index

Effect of MELANOTAN, [Nle4,D-Phe7]-α-MSH, on Melanin Synthesis in Humans With MC1R Variant Alleles

Journal: Peptides
Year: 2006
PMID: 16293341
DOI: 10.1016/j.peptides.2004.12.038
Research Context: Melanotan/NDP-MSH, MC1R variants, human melanogenesis, pigmentation, and controlled research.

Approaches to Increasing Skin Melanin With MSH Analogs and Synthetic Melanins

Year: 2001
PMID: 11434562
DOI: 10.1034/j.1600-0749.2001.140304.x
Research Context: Melanotan I, Melanotan II, α-MSH analogues, melanogenesis, pigmentation research, and photobiology.

Melanocortin Peptide Therapeutics: Historical Milestones, Clinical Studies and Commercialization

Year: 2006
PMID: 16412534
Research Context: Melanotan I, Melanotan II, melanocortin receptors, peptide development, and historical clinical research.

Pharmacokinetics and Pharmacodynamics of Afamelanotide and Its Clinical Use in Treating Dermatologic Disorders

Year: 2017
PMID: 28063031
Research Context: Afamelanotide, MC1R, melanogenesis, pharmacokinetics, controlled-release formulations, and regulated clinical development.

Risks of Unregulated Use of Alpha-Melanocyte-Stimulating Hormone Analogues: A Review

Year: 2017
PMID: 28266027
DOI: 10.1111/ijd.13585
Research Context: Melanotan I and II, unregulated α-MSH analogue use, safety concerns, and clinical-risk literature.

Researchers can review broader Melanotan 1, afamelanotide and α-MSH literature indexed by PubMed for peer-reviewed research.

Frequently Asked Questions

What is Melanotan 1?

Melanotan 1 is a synthetic 13-amino-acid analogue of α-MSH. It is also known as afamelanotide and NDP-MSH.

What is the Melanotan 1 sequence?

The sequence is:

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂

Is Melanotan 1 the same as afamelanotide?

The molecular peptide commonly called Melanotan 1 corresponds to afamelanotide/NDP-MSH. However, the Protide Health research vial is not equivalent to the FDA-approved afamelanotide implant formulation.

What is the molecular formula?

The molecular formula is:

C78H111N21O19

What is the molecular weight?

The molecular weight is approximately:

1646.87 g/mol

What is the CAS number?

The CAS number is:

75921-69-6

What is the PubChem CID?

The PubChem identifier is:

CID 16197727

What does Melanotan 1 peptide research investigate?

Research includes MC1R signaling, melanogenesis, cAMP pathways, melanocyte biology, eumelanin formation, receptor genetics, and α-MSH structure-activity relationships.

What is the difference between Melanotan 1 vs 2?

Melanotan 1 is a linear 13-amino-acid α-MSH analogue, whereas Melanotan II is a cyclic seven-amino-acid melanocortin analogue with broader receptor pharmacology.

What about Melanotan 2 vs 1?

The same structural distinction applies. The compounds are related but are not chemically or pharmacologically interchangeable.

Are Melanotan 1 before and after photos scientific evidence?

No. Melanotan 1 before and after photographs generally lack standardized experimental controls and cannot establish efficacy or safety.

What is the Melanotan 1 dosage?

Protide Health does not provide human melanotan 1 dosage instructions. The 10mg quantity represents vial contents only.

Does Protide Health provide a Melanotan 1 dosage chart PDF?

No. No melanotan 1 dosage chart pdf or human administration schedule is provided because this material is intended exclusively for laboratory research.

Is Melanotan 1 for sale for human tanning?

No. Although melanotan 1 for sale is a common search phrase, Protide Health supplies this product solely for qualified laboratory research.

Is Melanotan 1 FDA approved?

A specific controlled-release afamelanotide implant is FDA approved for a defined medical indication. The Protide Health 10mg lyophilized research vial is not that approved pharmaceutical product and is not FDA approved for human use.

What purity does Protide Health specify?

Protide Health specifies 99% purity, with HPLC-MS verification and third-party testing.

Is Melanotan 1 intended for human use?

No. It is supplied solely for melanocortin-receptor, pigmentation-pathway, biochemical, cellular, molecular, analytical, in-vitro, and qualified preclinical research.

Laboratory Terms & Compliance

Laboratory Research Use Only

This Melanotan 1 product is supplied exclusively for laboratory research, melanocortin-receptor research, pigmentation-pathway studies, analytical testing, biochemical experimentation, cellular research, in-vitro investigation, and qualified preclinical experimentation.

It is not intended for human or veterinary consumption, medical use, tanning, cosmetic use, pigmentation treatment, diagnostic use, therapeutic use, injection, implant use, or clinical administration.

No human dosage, injection schedule, tanning protocol, UV-exposure plan, dosage chart, body-weight calculation, treatment cycle, or human-use preparation instructions are provided.

The purchaser is responsible for appropriate laboratory handling, storage, and use under applicable institutional, federal, state, and local requirements.

For research use only.